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T lymphocytes undergo maturation in the thymus, a small gland located just above the heart, and are then released into the bloodstream. T lymphocyte egress from the thymus is essential for immune surveillance and to fight various types of infections. Sphingosine-1-phosphate (S1P) is a lipid molecule found at high levels in the blood and low levels in most tissues. Mature T cells produce a cell surface receptor that recognizes S1P, allowing the S1P chemical gradient to attract them into the bloodstream once they have completed their education in the thymus. her latest blogHowever, the precise mechanisms that control T lymphocyte egress are not fully understood. Thymic dendritic cells have a well-established role in antigen presentation and immune tolerance in the body. In addition to this role, dendritic cells also act as metabolic gatekeepers of lymphocyte trafficking. The team showed that thymic dendritic cells take up S1P, a blood borne lipid mediator, and metabolize it through the actions of an enzyme called S1P lyase, generating a localized S1P gradient that facilitates T lymphocyte egress into the blood In light of the fact that dendritic cells are known to continually traffic throughout the body surveying for the presence of infectious agents, the team’s observations raise the possibility that dendritic cells could potentially control the release of T lymphocytes in response to various disease states or conditions. These findings provide a deeper understanding of how the body regulates lymphocyte trafficking. “T cells are needed to orchestrate the body’s immune response against pathogenic organisms and also against cancer cells,” says UCSF Benioff Oakland’s Dr. http://camilaburnscenter.universitypunjabi.org/2016/09/15/finding-answers-for-reasonable-secrets-of-medical-studentJulie Saba, one of the study’s authors.
For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/chr-rda120516.php